-<ClinicalUseIssue xmlns="http://hl7.org/fhir">
 <!-- ISO name: (id is generated on the fly)  -->
 <id value="SPIOInhaler28mg-d3e100"/>
 <type value="interaction"/>
-<subject>
 </subject>
 <!-- ISO name: /MedicinalProduct/Interactions/InteractionsText  -->
 <description value="Other medicinal products that have been reported to increase the potential toxicity of parenterally administered aminoglycosides include:\n- amphotericin B, cefalotin, ciclosporin, tacrolimus, polymyxins (risk of increased nephrotoxicity);\n- platinum compounds (risk of increased nephrotoxicity and ototoxicity);\n- anticholinesterases, botulinum toxin (neuromuscular effects)."/>
 <!-- ISO name: /MedicinalProduct/Interactions  -->
-<interaction>
 <!-- ISO name: /MedicinalProduct/Interactions/Interactant  -->
-<interactant>
 <!-- ISO name: /MedicinalProduct/Interactions/Interactant  -->
-<itemCodeableConcept>
-<coding>
 <system value="http://ema.europa.eu/fhir/interactant"/>
 <code value="amphotericinB"/>
 </coding>
 </itemCodeableConcept>
 </interactant>
 <!-- ISO name: /MedicinalProduct/Interactions/Interactant  -->
-<interactant>
 <!-- ISO name: /MedicinalProduct/Interactions/Interactant  -->
-<itemCodeableConcept>
-<coding>
 <system value="http://ema.europa.eu/fhir/interactant"/>
 <code value="cefalotin"/>
 </coding>
 </itemCodeableConcept>
 </interactant>
 <!-- ISO name: /MedicinalProduct/Interactions/Interactant  -->
-<interactant>
 <!-- ISO name: /MedicinalProduct/Interactions/Interactant  -->
-<itemCodeableConcept>
-<coding>
 <system value="http://ema.europa.eu/fhir/interactant"/>
 <code value="tacrolimus"/>
 </coding>
 </itemCodeableConcept>
 </interactant>
 <!-- ISO name: /MedicinalProduct/Interactions/Interactant  -->
-<interactant>
 <!-- ISO name: /MedicinalProduct/Interactions/Interactant  -->
-<itemCodeableConcept>
-<coding>
 <system value="http://ema.europa.eu/fhir/interactant"/>
 <code value="polymyxins"/>
 </coding>
 </itemCodeableConcept>
 </interactant>
 <!-- ISO name: /MedicinalProduct/Interactions/Interactant  -->
-<interactant>
 <!-- ISO name: /MedicinalProduct/Interactions/Interactant  -->
-<itemCodeableConcept>
-<coding>
 <system value="http://ema.europa.eu/fhir/interactant"/>
 <code value="platinumcompounds"/>
 </coding>
 </itemCodeableConcept>
 </interactant>
 <!-- ISO name: /MedicinalProduct/Interactions/InteractionsType  -->
-<type>
-<coding>
 <system value="http://ema.europa.eu/fhir/interactionsType"/>
 <code value="WeakInhibitorsofP-gp"/>
 </coding>
 </type>
 <!-- ISO name: /MedicinalProduct/Interactions/InteractionsEffect  -->
-<effect>
-<concept>
-<coding>
 <system value="http://ema.europa.eu/fhir/interactionseffect"/>
 <code value="Riskofincreasednephrotoxicity"/>
 </coding>
 </concept>
 </effect>
 </interaction>
 </ClinicalUseIssue>